Targeting Pain

A multifaceted approach to a multifaceted subject.

We know that pain is complex. It involves multiple cell types, receptors, and signaling molecules. There’s neuropathic (nerve) pain and nociceptive (tissue) pain. There are the central and peripheral nervous systems; the NaV, K+, TRPV, and acid-sensing ion channels; modulators that adjust the behavior of those channels; the P2X7 receptors; and much more.

Thankfully, you can find all the tools you need to study pain, right here.

Popular Antibodies

Transient receptor potential cation channel subfamily V member 1, Capsaicin receptor, Vanilloid receptor 1, OTRPC1

A highly specific antibody directed against an epitope of the rat protein. It has been designed to recognize TRPV1 from mouse, rat, and human samples.

Applications:
ICC, IF, IFC, IHC, WB

Host:
Rabbit

Sizes:
25 μl, 50 μl, 0.2 ml (free sample available)

Sodium channel voltage-gated type VIII alpha subunit, NaCh6, PN4, CerIII

A highly specific antibody directed against an epitope of the rat protein. It has been designed to recognize NaV1.6 sodium channel from rat, human, and mouse samples.

Applications:
ICC, IF, IHC, WB

Host:
Rabbit

Sizes:
25 μl, 50 μl, 0.2 ml (free sample available)

Purinergic receptor P2X7, P2RX7, P2Z, ATP receptor

A highly specific antibody directed against an epitope of the rat protein. It has been designed to recognize P2X7 purinergic receptor from rat, mouse, and human samples.

Applications:
ICC, IF, IHC, IP, WB

Host:
Rabbit

Sizes:
25 μl, 50 μl, 0.2 ml (free sample available)

OTRPC4, VRL-2, VR-OAC, TRP12

A highly specific antibody directed against an epitope of the rat protein. It has been designed to recognize TRPV4 from human, rat, and mouse samples.

Applications:
ICC, IF, IFC, IHC, IP, WB

Host:
Rabbit

Sizes:
25 μl, 50 μl, 0.2 ml (free sample available)

Brain type I sodium channel, BI, Sodium channel protein type 1 subunit α

A highly specific antibody directed against an epitope of the rat protein. It has been designed to recognize NaV1.1 from rat, human, and mouse samples.

Applications:
ICC, IF, IHC, IP, WB

Host:
Rabbit

Sizes:
25 μl, 50 μl, 0.2 ml (free sample available)

Popular Toxins

TTX
A Classic Blocker of a Subset of NaV Channels

A highly pure, natural, and biologically active compound.

Purity:
>99% (HPLC)

MW:
319.27 Da

Sizes:
50 µg - 5 mg

Starts from:
$124 (free sample available)

Neurotoxin 2, Toxin ATX-II, As2, Anemonia viridis toxin 2, Av2, Delta-actitoxin-Avd1c 2
A Modulator of NaV Channels

A highly pure, synthetic, and biologically active peptide toxin.

Purity:
>98% (HPLC)

MW:
4935 Da

Sizes:
50 µg - 10 mg

Starts from:
$436 (free sample available)

SNX-124
A Blocker of N-Type Ca2+ Channels

A highly pure, synthetic, and biologically active peptide toxin.

Purity:
>99% (HPLC)

MW:
3037 Da

Sizes:
50 µg - 10 mg

Starts from:
$119 (free sample available)

M-TRTx-Gr1a, M-theraphotoxin-Gr1a, GsMTx4
A Blocker of NaV1.7, TRPC1, TRPC6 and Piezo1 Channels

A highly pure, synthetic, and biologically active peptide toxin.

Purity:
>98% (HPLC)

MW:
4096 Da

Sizes:
0.1 mg - 10 mg

Starts from:
$207 (free sample available)

ω-agatoxin-Aa4a, ω-AGTX-Aa4a, ω-Aga-IVA, ω-agatoxin-4A
A Blocker of P/Q-Type CaV Channels

A highly pure, synthetic, and biologically active peptide toxin.

Purity:
>98% (HPLC)

MW:
5202 Da

Sizes:
50 µg - 10 mg

Starts from:
$225 (free sample available)

Popular Proteins

Brain-Derived Neurotrophic Factor
Human Brain-Derived Neurotrophic Factor, Recombinant, E. coli

A highly pure, recombinant, and biologically active protein.

Purity:
>98% (HPLC)​

MW:
27 kDa

Sizes:
1 µg - 1 mg

Starts from:
$68 (free sample available)

Nerve Growth Factor 2.5S
Native Mouse Nerve Growth Factor

A highly pure, natural, and biologically active protein.

Purity:
>95% (HPLC)

MW:
26 kDa

Sizes:
10 µg - 1 mg

Starts from:
$83 (free sample available)

Glial Cell Line-Derived Neurotrophic Factor
Human Glial-Derived Neurotrophic Factor, Recombinant, E. coli

A highly pure, recombinant, and biologically active protein.

Purity:
>98% (HPLC)

MW:
30.1 kDa

Sizes:
5 µg - 1 mg

Starts from:
$68 (free sample available)

Nerve Growth Factor 2.5S
Native Mouse Nerve Growth Factor

A highly pure, natural, and biologically active protein.

Purity:
99% (HPLC)

MW:
26 kDa

Sizes:
10 µg - 1 mg

Starts from:
$99 (free sample available)

Nerve Growth Factor 7S
Native Mouse Nerve Growth Factor 7S

A highly pure, natural, and biologically active protein.

Purity:
>98% (HPLC)

MW:
130 kDa

Sizes:
10 µg - 1 mg

Starts from:
$73 (free sample available)

Popular Biomolecules

5-Phosphono-D-norvaline, D-Norvaline, 5-Phosphono-, D(-)-APV, D-2-Amino-5-phosphonovaleric acid, D-2-Amino-5-phosphopentanoic acid, D(-)-AP-5
A Competitive NMDA Receptor Antagonist

A highly pure, synthetic, and biologically active compound.

Purity:
>95%

MW:
197.1 Da

Sizes:
1 mg - 100 mg

Starts from:
$47 (free sample available)

A Blocker of T-Type CaV Channels

A highly pure, synthetic, and biologically active compound.

Purity:
>96% (HPLC)

MW:
431 Da

Sizes:
5 mg - 50 mg

Starts from:
$154 (free sample available)

AMPA/Kainate Receptor Antagonist

A highly pure, synthetic, and biologically active compound.

Purity:
>98%

MW:
276.1 Da

Sizes:
1 mg - 100 mg

Starts from:
$35 (free sample available)

Lidocaine N-ethyl chloride
A Local Anesthetic Blocker of NaV Channels

A highly pure, synthetic, and biologically active compound.

Purity:
>99% (HPLC)

MW:
298.85 Da

Sizes:
50 mg - 1 g

Starts from:
$132 (free sample available)

Reciniferatoxin, RTX
A Potent and Selective Activator of TRPV1 Channel

A highly pure, natural, and biologically active compound.

Purity:
95-98% (HPLC)

MW:
628.72 Da

Sizes:
0.5 mg - 2.5 mg

Starts from:
$1,434 (free sample available)

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